Sickle Cell Disease

Sickle cell disease is a genetic disease where the body produces abnormal crescent- or sickle-shaped red blood cells. These cells don't last as long as normal, round red blood cells, which leads to anaemia. The sickle-shaped cells also get stuck in blood vessels, blocking blood flow which can cause pain and organ damage.

Follow the links below to find information about sickle cell disease.

Updated January 2008

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21 Resources Found
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Title:   Drugs for preventing red blood cell dehydration in people with sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Sickle cell disease is an inherited condition that causes red blood cells to become sickle shaped when they lose water. This leads to a high risk of the blood vessels becoming blocked. Such blockages can cause pain, stroke and damage to organs. Recent t...
Date:   Jul 2007
Title:   Preoperative blood transfusions for sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Once they have given up their oxygen, red blood cells in people with sickle cell disease become shaped like crescents. These cells can block blood vessels, which causes problems throughout the body. People with sickle cell disease often need surgery, bu...
Date:   May 2001
Title:   Malaria chemoprophylaxis in sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   In areas where malaria is common, malaria drug prophylaxis benefits people with sickle cell disease Sickle cell disease is a blood disorder, and means the part of the red blood cell that carries oxygen from the lungs to the body tissues (haemoglobin) is...
Date:   Aug 2006
Title:   Hydroxyurea for sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Haemoglobin is the substance within the red blood cells that carries oxygen around the body. Sickle cell disease (SCD) is an inherited genetic disorder where there are problems with the haemoglobin. Crystals form in the red blood cells and block the blo...
Date:   Feb 2001
Title:   Blood transfusion for preventing stroke in people with sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Sickle cell disease causes decreased red blood cells (anaemia), reduced oxygen to tissues and problems throughout the body. Sickled red blood cells can block cerebral blood vessels, leading to strokes. The review found regular blood transfusions reduce ...
Date:   Oct 2001
Title:   Inhaled nitric oxide for acute chest syndrome in people with sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Inhaled nitric oxide for acute chest syndrome in people with sickle cell diseaseSickle cell disease is an inherited blood disorder affecting approximately 250 million people worldwide. Sickle-shaped red blood cells which are characteristic of sickle cel...
Date:   Oct 2007
Title:   Piracetam for reducing the incidence of painful sickle cell disease crises
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Sickle cell disease is one of the most common genetic disorders with approximately 250 million people (5% of the world's population) carrying a potentially pathological gene. It is characterised by the presence of distorted sickle-shaped red blood cells...
Date:   Feb 2007
Title:   Steroid hormones for contraception in women with sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Whether women with sickle cell anemia should use hormonal birth control is unknown. Sickle cell anemia is a blood disease. This type of anemia also causes bone pain known as sickle pain crises. A concern is that women with this disease using hormonal bi...
Date:   Dec 2006
Title:   Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Sickle cell disease is an inherited blood disorder. People with sickle cell disease often experience acute chest syndrome, although it is not known why. Acute chest syndrome can cause fever, coughing, chest pain, shortness of breath and pain, and can be...
Date:   May 2003
Title:   Splenectomy versus conservative management for acute sequestration crises in people with sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   In some people with sickle cell disease, red blood cells become trapped and destroyed in the spleen. This damages the spleen, which may become enlarged leading to splenic sequestration crises. These crises consist of abdominal pain, rapid heart rate and...
Date:   Aug 2002
Title:   Fluid replacement therapy for acute episodes of pain in people with sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Sickle cell disease is a common genetic disorder characterised by periodic episodes of pain which usually happen again and again throughout life. These episodes occur when sickled cells obstruct blood vessels. The degree of pain may range from a mild di...
Date:   Jan 2008
Title:   Pneumococcal vaccines for sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Pneumococcal bacteria are a common cause of infection, including pneumonia and meningitis, which can be life-threatening. People with sickle cell disease are particularly susceptible to pneumococcal infection. Infants under two years of age are particul...
Date:   Sep 2003
Title:   Pain management for sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Some people with sickle cell disease get pain. The pain usually occurs in episodes but it can be chronic. Pain is often poorly managed. This review studied different types of pain-relieving medicines. There were no studies on chronic pain. Seven papers ...
Date:   Feb 2006
Title:   Psychological therapies for sickle cell disease and pain
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Based on the information available, the authors cautiously believe that some types of psychological therapies may help people to cope with sickle cell disease and related pain. These therapies are patient education, and techniques termed 'cognitive' (ha...
Date:   Jan 2002
Title:   Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   People with sickle cell disease (SCD) are especially prone to respiratory infections and blood poisoning. These infections are often caused by pneumococcal bacteria. Infections occur partly due to the spleen not working correctly, but also because damag...
Date:   May 2002
Title:   Treatments for priapism in boys and men with sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Priapism (the prolonged painful erection of the penis) is common in males with sickle cell disease (SCD). The length of time priapism lasts differs for different types and so does the medical treatment for it. Self-management approaches may be helpful. ...
Date:   Aug 2004
Title:   Antibiotics for treating acute chest syndrome in people with sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Sickle cell disease affects millions of people throughout the world. Acute chest syndrome is a major cause of illness and death in people with sickle cell disease. Symptoms include fever, chest pain and a raised white blood cell count. Acute infection o...
Date:   Feb 2007
Title:   Neonatal screening for sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Sickle cell diseases are inherited and affect mainly people of African origin. The red blood cells are abnormally (sickle) shaped, which can lead to life-threatening complications. They are most likely to be fatal in the first few years of life since af...
Date:   May 2008
Title:   Treatment for avascular necrosis of bone in people with sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   There is currently insufficient evidence, in the form of randomised controlled trials, to assess the beneficial and harmful effects of specific therapies for avascular necrosis of bone in people with sickle cell disease. High quality randomised controll...
Date:   Aug 2004
Title:   Phytomedicines (medicines derived from plants) for sickle cell disease
Publisher:   John Wiley and Sons, Ltd. for The Cochrane Collaboration
Description:   Sickle cell disease (SCD) is a recessively inherited disorder of haemoglobin and is associated with complications and a reduced life expectancy. Phytomedicines encompass much of what populations most affected would encounter in terms of plant-remedies f...
Date:   May 2004
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